Hemicell™ (β-Mannanase)

An energy sparing enzyme

β-Mannans (beta-galactomannans) are antinutritive fibres found in common feed ingredients, including soybean meal and other leguminous feeds¹. β-Mannans have a molecular pattern similar to some pathogens, which trigger a Feed-Induced Immune Response (FIIR) in poultry^2,3. This unnecessary innate immune system stimulation consumes energy and other valuable nutrients.

Hemicell™ breaks down β-mannans to spare energy for performance. Whilst most enzyme products are energy-releasing enzymes—they "open up" feed components the animal is unable to access on its own - Hemicell™ is an energy-sparing enzyme. By breaking down β-mannans in feed^3,4, Hemicell™ minimises the metabolisable energy (ME) loss caused by the FIIR from β-mannans, allowing more energy to be available for growth and performance⁴.

Important Safety Information

Always read and follow the label directions.

Withholding Periods

Hemicell™ is considered a ‘Generally Recognised As Safe’ (GRAS) product and has no withholding period or restrictions when used in combination with other feed ingredients.

Directions for Use

Add 0.22 - 0.40 kg of Hemicell™ HT directly into the feed mixer per metric ton of feed. Hemicell™ HT is intended for use in feed that will be pelleted as it has been shown to retain more than 80% activity under pelleting temperatures up to 88 °C.

References

¹ Hsiao, H., Anderson, D. and Dale, N. 2006. "Levels of β-mannan in Soybean Meal." Poultry Sci. 85:1430-1432.

²Ausubel, F. 2005. "Are innate immune signaling pathways in plants and animals conserved?" Nature Immunol. 6(10): 973-979.

³Zhang, L. and Tizard, I. 1996. "Activation of a mouse macrophage cell line by acemannan: The major arbohydrate fraction from Aloe vera gel." Immunopharmacology. 35, 119-128.

⁴ Korver, D. 2006 "Overview of the Immune Dynamics of the Digestive System." J. Appl. Poultry Res. 15: 123-135.